Myelinated fibers are organized into distinct domains that are necessary for saltatory conduction. These domains include the nodes of Ranvier and the flanking paranodal regions where glial cells closely appose and form specialized septate-like junctions with axons. These junctions contain a Drosophila Neurexin IV-related protein, Caspr/Paranodin (NCP1). Mice that lack NCP1 exhibit tremor, ataxia, and significant motor paresis. In the absence of NCP1, normal paranodal junctions fail to form, and the organization of the paranodal loops is disrupted. Contactin is undetectable in the paranodes, and K+ channels are displaced from the juxtaparanodal into the paranodal domains. Loss of NCP1 also results in a severe decrease in peripheral nerve conduction velocity. These results show a critical role for NCP1 in the delineation of specific axonal domains and the axon-glia interactions required for normal saltatory conduction.
Copyright © 2001 Cell Press.
Neuron, Vol 30, 369-383, May 2001
Article
Axon-Glia Interactions and the Domain Organization of Myelinated Axons Requires Neurexin IV/Caspr/Paranodin
1Cardiovascular Research Institute, Department of Medicine, Department of Biochemistry and Molecular Biology, Mount Sinai School of Medicine, New York, NY 10029 USA
2Department of Cell Biology, Mount Sinai School of Medicine, New York, NY 10029 USA
3Department of Physiology and Neuroscience and Rusk Institute, New York University School of Medicine, New York, NY 10016 USA
4Howard Hughes Medical Institute, Department of Molecular and Human Genetics, Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030 USA
Corresponding author
Manzoor A. Bhat
212 241 0033 (phone)
212 828 4178 (fax)
bhatm01@doc.mssm.edu
Summary
Footnotes
6These authors contributed equally to this work.
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