Neuron

Cell Press

26 December, 2008
Volume 60, Issue 6

Volume 60, Issue 6

On the cover: Analysis of genome-scale gene expression data demonstrates robust parcellation of the hippocampus into discrete domains based on unique and combinatorial expression patterns. The cover image shows reciprocal gene expression patterns delineating the septal/distal (red) versus temporal/proximal (green) portions of the hippocampus CA3 region using double fluorescent in situ hybridization. Gene pairs from upper right to lower left are Fmo1 (red) and Mas1 (green), Itga7 (red) and Plagl1 (green), and Loxl1 (red) and Coch (green), all counterstained with DAPI (blue). The background heat map represents complex combinatorial expression patterns subdividing the long axis of CA3 from septal (red) to temporal (green). For details, see the paper by Thompson et al. (pp. 1010–1021).

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CURRENT ISSUE

		On the Cover \| Hippocampal Gene Map Thompson et al. use genome-scale gene expression data to examine hippocampal architecture and discover new principles of genetic parcellation and connectivity.
		Featured Article \| Seeing as Monkeys Do FREE By comparing response patterns in monkey and human cortex, Kriegeskorte and colleagues find that object information is categorized similarly in both species.
		Featured Review \| Epigenetic Regulation FREE Borelli et al. review how epigenetic regulation of gene expression serves as a powerful mechanism to regulate chromatin remodeling and brain functions.

SPOTLIGHT ON

	Systems \| What a Monoclonal Nose Knows Fleischmann et al. study the neural representation of odorants in the brain in a mouse with a "monoclonal nose" in which sensory neurons express a single odorant receptor.
	Physiology \| Targeted Plasticity for mGluR7 Pelkey et al. discover a critical role for the trafficking of mGluR7 in controlling the bidirectional plasticity within a feed-forward inhibitory circuit in the hippocampus.
	Evolution \| Thermal Splicing in Drosophila Low et al. study the linkage between thermal regulation of RNA splicing, circadian rhythms, and the ecological adaptation of behavior. Preview by Wijnen and Young.

COLLECTIONS

Neuron has an established history of high impact and insightful review articles and issues and has also been a leading force in the community to feature technological advances, with our Neurotechniques, and their expert explanation, with our Primers. Now we collect together in one online archive the best of Neuron’s review material.

	Reviews	Primers
	Special Issues	Neurotechniques

ANNIVERSARY ISSUE

CELEBRATING 20 YEARS
OF EXCITING NEUROSCIENCE

2008 marks Neuron’s twentieth anniversary. To celebrate this milestone we have commissioned a special issue to reflect on both the history of the journal and some of the notable advances in neuroscience over the last several remarkable decades. In celebration of our anniversary, all content for this special issue is free to our online readership.

Editorial | Table of Contents

REFLECTIONS

In commemoration of the journal’s beginnings, we invited authors of research articles in the first issue of Neuron to look back at their original paper and comment on how the field has evolved since then. The first issue of the journal set a high standard and it is a testimony to the prescience of the journal’s founding editors — Zach Hall, A.J. Hudspeth, Eric Kandel, and Louis Reichardt — that the topics covered in the Volume 1, Issue 1 continue to be relevant even today.

First Issue Table of Contents | Reflections

NEUROVIEWS

With NeuroViews, the journal introduces a new review format aimed at discussion of issues at the intersection of neuroscience and society.

		Gazzaniga overviews the emerging intersections between neuroscience and the law.		The relationship between neuroscience and philosophy is explored by Chuchland.
		Camerer discusses the goals of Neuroeconomics and the means for achieving them.		Altevogt, Hanson & Leshner introduce “Molecules to Minds: Grand Challenges.”

PERSPECTIVES

In this series of Perspectives, we asked researchers to discuss the state of their respective fields looking back, forward, and within, and offer their unique insight into the future trajectory of neuroscience.

		Abbott reviews theoretical neuroscience and how it has and can shape neuroscience.		Lichtman and Smith introduce tools at the intersection of imaging and neuroscience.
		What are neural stem cells good for? Kokovay, Shen & Temple discuss their promise.		Dolan reflects on the rapid growth of neuroimaging of cognition as a dominant field
		The diversity of brain plasticity mechanisms are reviewed by Nelson and Turrigiano.		Bezanilla offers a personal history on the historical development of ion channel field.
		Donoghue explains how neural interface systems will bridge neuroscience and clinic.		Sudhof and Malenka on strategic challenges facing next generation neuroscientists.
		Miller and Wilson on the impact of multiunit technology for understanding behavior.		Barres suggests that fully understanding glia is critical to conceptualizing the brain.
		Frith and Frith propose an explicit/implicit processing framework for social cognition.		The molecular biology of gene expression in the CNS is reviewed by Qiu and Ghosh.