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May 8, 2008: 58 (3)

"Functional Architecture of the Motor Homunculus"
[Cover Caption]

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To Cross or Not to Cross: Alternatively Spliced Forms of the Robo3 Receptor Regulate Discrete Steps in Axonal Midline Crossing
Douglas L. Black and S. Lawrence Zipursky
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297
Silencing the Cochlear Amplifier by Immobilizing Prestin
Ulrich Müller and Peter Gillespie
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299
What to Do, or How to Do It?
Bijan Pesaran and J. Anthony Movshon
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301
Finding Gamma
Pascal Fries, René Scheeringa, and Robert Oostenveld
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303
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The Reorienting System of the Human Brain: From Environment to Theory of Mind
Maurizio Corbetta, Gaurav Patel, and Gordon L. Shulman
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306
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Alternative Splicing of the Robo3 Axon Guidance Receptor Governs the Midline Switch from Attraction to Repulsion
Zhe Chen, Bryan B. Gore, Hua Long, Le Ma, and Marc Tessier-Lavigne
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325
Prestin-Based Outer Hair Cell Motility Is Necessary for Mammalian Cochlear Amplification
Peter Dallos, Xudong Wu, Mary Ann Cheatham, Jiangang Gao, Jing Zheng, Charles T. Anderson, Shuping Jia, Xiang Wang, Wendy H.Y. Cheng, Soma Sengupta, David Z.Z. He, and Jian Zuo
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333
Cannabinoid Receptor Blockade Reveals Parallel Plasticity Mechanisms in Different Layers of Mouse Visual Cortex
Cheng-Hang Liu, Arnold J. Heynen, Marshall G. Hussain Shuler, and Mark F. Bear
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340
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An RNAi Screen Identifies Genes that Regulate GABA Synapses
Amy B. Vashlishan, Jon M. Madison, Mike Dybbs, Jihong Bai, Derek Sieburth, Queelim Ch'ng, Masoud Tavazoie, and Joshua M. Kaplan
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346
A Yeast Genetic Screen Reveals a Critical Role for the Pore Helix Domain in TRP Channel Gating
Benjamin R. Myers, Christopher J. Bohlen, and David Julius
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362
Olfactory CNG Channel Desensitization by Ca2+/CaM via the B1b Subunit Affects Response Termination but Not Sensitivity to Recurring Stimulation
Yijun Song, Katherine D. Cygnar, Botir Sagdullaev, Matthew Valley, Sarah Hirsh, Aaron Stephan, Johannes Reisert, and Haiqing Zhao
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374
K+ Channels at the Axon Initial Segment Dampen Near-Threshold Excitability of Neocortical Fast-Spiking GABAergic Interneurons
Ethan M. Goldberg, Brian D. Clark, Edward Zagha, Mark Nahmani, Alev Erisir, and Bernardo Rudy
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387
Homeostatic Matching and Nonlinear Amplification at Identified Central Synapses
Hokto Kazama and Rachel I. Wilson
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401
Assessing the Function of Motor Cortex: Single-Neuron Models of How Neural Response Is Modulated by Limb Biomechanics
Robert Ajemian, Andrea Green, Daniel Bullock, Lauren Sergio, John Kalaska, and Stephen Grossberg
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414
Transient Induced Gamma-Band Response in EEG as a Manifestation of Miniature Saccades
Shlomit Yuval-Greenberg, Orr Tomer, Alon S. Keren, Israel Nelken, and Leon Y. Deouell
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429
A Map for Horizontal Disparity in Monkey V2
Gang Chen, Haidong D. Lu, and Anna W. Roe
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442
Value Representations in the Primate Striatum during Matching Behavior
Brian Lau and Paul W. Glimcher
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451
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The Barista on the Bus: Cellular and Synaptic Mechanisms for Visual Recognition Memory
Alison L. Barth and Mark E. Wheeler
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464
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On the cover: The discovery of somatotopic organization within the motor cortex—often graphically depicted in the striking image of a motor homunculus—occurred more than a century ago. Despite the general understanding that neighboring regions of motor cortex control neighboring body parts, over a century of controversy has ensued regarding how, exactly, this control occurs. In particular, does the motor cortex encode the muscular details of motor control or does it encode high-level movement commands, perhaps even stereotyped behaviors? Through an analysis of single neurons, Ajemian et al. (pp. 414–428) suggest that the muscular details of movements are indeed represented in motor cortical activity. The cover depicts an atypical motor homunculus, alluding to the fact that not only are body parts separately represented in motor cortex, but potentially the corresponding geometrical constraints and dynamical requirements of motion for each individuated body part as well. Cover image by Robert Ajemian and Emily Romano.

Featured Article

Transient Induced Gamma-Band Response in EEG as a Manifestation of Miniature Saccades
Shlomit Yuval-Greenberg, Orr Tomer, Alon S. Keren, Israel Nelken, and Leon Y. Deouell
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The induced gamma-band EEG response (iGBR) recorded on the scalp is widely assumed to reflect synchronous neural oscillation associated with object representation, attention, memory, and consciousness. The most commonly reported EEG iGBR is a broadband transient increase in power at the gamma range ∼200–300 ms following stimulus onset. A conspicuous feature of this iGBR is the trial-to-trial poststimulus latency variability, which has been insufficiently addressed. Here, we show, using single-trial analysis of concomitant EEG and eye tracking, that this iGBR is tightly time locked to the onset of involuntary miniature eye movements and reflects a saccadic “spike potential.” The time course of the iGBR is related to an increase in the rate of saccades following a period of poststimulus saccadic inhibition. Thus, whereas neuronal gamma-band oscillations were shown conclusively with other methods, the broadband transient iGBR recorded by scalp EEG reflects properties of miniature saccade dynamics rather than neuronal oscillations.